Nutritional Sciences 623 - Advanced Nutrition: Minerals
Molecular Nutrition of Essential Mineral Elements


NS Home


Rev: 9/23/2008
Instructors: Drs. Roger A. Sunde and David
J. Eide
Credits: 1
Hours: Fall 2008: 9:55 WF, Room 290 Nutritional Sciences
Optional Discusssion Section:
Prerequisites: Upper division nutrition course
(510), biochemistry (501/602), physiology (335)
Website and Handout pdfs: http://www.nutrisci.wisc.edu/NS623/index.html
Handouts, Worksheets and Readings can be downloaded from this site.
Course
Description: This course meets in the first half of the semester,
and is one of several 1-credit courses in the graduate nutritional sciences
curriculum. The course is taught in a lecture format and covers molecular
nutrition of minerals, with a focus on evolution of mineral roles and requirements
and nutrient regulation. The course will use recommended texts for foundation
material as well as research papers to provide in-depth coverage and illustrate
emerging themes in molecular trace mineral nutrition.
Objectives:
The specific course objectives are to:
- Review current status of mineral element nutrition;
- Review mineral element deficiency and requirements;
- Develop a basic understanding of the roles of minerals in metabolism,
and in health and disease;
- Focus on and emphasize: Themes in trace mineral nutrition; Novel molecular
biology; Models at multiple phylogenetic levels; Homeostasis;
- Build cases for general concepts and future research needs.
Grades:
A, B, C, F; The final grade will be determined as follows:
- Mid-course take-home exam: 25% of the course grade will be based on
performance in a take-home exercise (after Se and Zn sections).
- Class exercises: 15% of the course grade will be based on homework
and in-class exercises.
- Final take-home exam: 60% of the course grade will be based on a take-home
exercise that will summarize and intergrate course material (at end of
course).
Texts (all optional):
- Stipanuk, M. H. 2006. Biochemical,
Physiological, and Molecular Aspects of Human Nutrition, 2nd Ed.,
W.B. Sanders, NY.
- Bowman, B.A. & Russell, R.M. 2006. Present
Knowledge in Nutrition, Vol. 1, 9th ed. ILSI Press, Washington,
D.C. (2001 ed. also acceptable)
References: (for additional information):
- O'Dell, B.L. & Sunde, R.A. (1997) Handbook of Nutritionally Essential
Mineral Elements. Marcel Dekker, Inc, New York.
- Food and Nutrition Board (1999) Dietary Reference Intakes for Calcium,
Phosphorus, Magnesium, Vitamin D, and Fluoride. National Academy Press,
Washington, D.C.
- Food and Nutrition Board (2000) Dietary Reference Intakes for Vitamin
C, Vitamin E, Selenium and Carotenoids. Pp. 1-486. National Academy Press,
Washington, D.C.
- Food and Nutrition Board (2001) Dietary Reference Intakes for Arsenic,
Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon,
Vanadium, and Zinc. National Academy Press, Washington, D.C.
Syllabus,
Handouts, Readings & Assignments:
Periodic Table
Atomic Weights
Electronic Configuration
Information Sheet
Sept 3: Essential Minerals
and General Roles (Sunde)
Lecture: 623 Intro Lectures
Homeostasis
Essentiality Definitions
Essential Mineral Elements
Article: DRI Introduction
Mineral Requirements Worksheet
(obtain values from original sources indicated below; due Wednesday, 9/10)
DRI summaries: Calcium etc. Vitamin
C (Se) Vitamin A (As
etc.) Water (K,Na,Cl)
Animal Requirements: Rats Swine
Chickens
Dairy Heifers
Cats 1986
Dogs 1985
Sept 5: Mineral Requirements,
Homeostasis and Nutrient Thermostats (Sunde)
Negative Feedback
Sept 10/12: Scientific
Revolution/Nutrition (Sunde)
Article: Schneider 1986
Sept 17/19: Selenium (Sunde)
Background: Selenium, PKN9 Chap 38 or Stipanuk Chap. 39
Lecture: 623 Se Lectures
Se Forms and Metabolism
Selenoprotein Molecular Biology
Control Points of Selenoprotein Gene
Expression
Exercise #2: Model Building
Article: Sunde 2005
Article: Kryukov 2003
Sept 26/26: Iron (Sunde)
Background: Iron, PKN9 Chap 34 or Stipanuk Chap. 36
Lecture: 623 Fe Lectures
Article: Casey 1989
Article: Nemeth 2004
Oct 1/3: Zinc (Eide)
Background: Zinc, PKN9 Chap 35 or Stipanuk Chap. 37
Lecture: 623 Zn Lectures
Review: Cousins 2007
Article: Weaver 2007
Article: Outten 2001
Oct 8/10: Copper (Eide)
Background: Copper, PKN9 Chap 36 or Stipanuk Chap. 37
Lecture: 623 Cu Lectures
Review: Puig 2002
Article: Nose 2006
Article: Petris2002
Oct 15/17: Newer Trace
Elements (Mo, I, Mn, F, Ni) (Sunde)
Background: B, Mn, Mo, and Other Trace Elements, Stipanuk Chap.
40,41
Lecture: 623 Mo and Mn Lectures
Lecture: 623 I, F, and Ni Lectures
Molybdenum Cofactor (MoCo) Biosynthesis
Article: Schwarz 2004
Background: Iodine, Stipanuk Chap. 38
I Metabolism
Article: Vanderpas 1993
Article: Hausinger 2003
Oct 22/24: Likely and
Potential Essential Elements (B, V, Si, Sn, Cr, As, W, Co, Cd, Li,
Pb) (Sunde)
Lecture: 623 Likely Essential Mineral Lectures
Article: Eckhert 1998
Article: Iwai 2006
Article: Busenlehner 2003
Take-Home Final Oct 29:
due Friday, November 7
Exam: Take-Home Exam and accompanying article