Nutritional Sciences 623 - Advanced Nutrition: Minerals

Molecular Nutrition of Essential Mineral Elements

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Rev: 8/31/2010

Instructors: Drs. Roger A. Sunde and David J. Eide
Credits: 1
Hours: Fall 2010: 9:55 MW, Room 290 Nutritional Sciences
Optional Discusssion Section:
Prerequisites: Upper division nutrition course (510), biochemistry (501/602), physiology (335)


Website and Handout pdfs: Full course materials for enrolled students available at Learn@UW. Handouts, Worksheets and Readings can be downloaded from this site. Some introductory materials available at: http://www.nutrisci.wisc.edu/NS623/index.html


Course Description: This course meets in the first half of the semester, and is one of several 1-credit courses in the graduate nutritional sciences curriculum. The course is taught in a lecture format and covers molecular nutrition of minerals, with a focus on evolution of mineral roles and requirements and nutrient regulation. The course will use recommended texts for foundation material as well as research papers to provide in-depth coverage and illustrate emerging themes in molecular trace mineral nutrition.


Objectives: The specific course objectives are to:

  1. Review current status of mineral element nutrition;
  2. Review mineral element deficiency and requirements;
  3. Develop a basic understanding of the roles of minerals in metabolism, and in health and disease;
  4. Focus on and emphasize: Themes in trace mineral nutrition; Novel molecular biology; Models at multiple phylogenetic levels; Homeostasis;
  5. Build cases for general concepts and future research needs.


Grades: A, B, C, F; The final grade will be determined as follows:

-


Texts (all optional):

References: (for additional information):


Syllabus, Handouts, Readings & Assignments:
Periodic Table
Atomic Weights
Electronic Configuration
Information Sheet


Sept 13: Essential Minerals and General Roles (Sunde)
Lecture: 623 Intro Lectures
Homeostasis
Essentiality Definitions
Essential Mineral Elements
Article: DRI Introduction
Exercise #1: Mineral Requirements Worksheet (obtain values from original sources indicated below; due Monday, 9/20)
DRI summaries: Calcium etc.   Vitamin C (Se)   Vitamin A (As etc.)   Water (K,Na,Cl)
Animal Requirements: Rats   Swine   Chickens   Dairy Heifers   Cats 1986   Dogs 1985


Sept 15: Mineral Requirements, Homeostasis and Nutrient Thermostats (Sunde)
Negative Feedback


Sept 20/22: Scientific Revolution/Nutrition (Sunde)
Article: Schneider 1986


Sept 27/29: Selenium (Sunde)
Background: Selenium, PKN9 Chap 38 or Stipanuk Chap. 39
Lecture: 623 Se Lectures
Se Forms and Metabolism
Selenoprotein Molecular Biology
Control Points of Selenoprotein Gene Expression
Exercise #2: Model Building
Review: Sunde 2006
Article: Kryukov 2003
Article: Barnes 2009


Oct 4/6: Iron (Eide)
Background: Iron, PKN9 Chap 34 or Stipanuk Chap. 36
Lecture: 623 Fe Lectures
Article: Casey 1989
Article: Nemeth 2004


Oct 11/13: Copper (Eide)
Background: Copper, PKN9 Chap 36 or Stipanuk Chap. 37
Lecture: 623 Cu Lectures
Review: Puig 2002
Article: Nose 2006
Article: Petris2002


Oct 18/20: Zinc (Eide)
Background: Zinc, PKN9 Chap 35 or Stipanuk Chap. 37
Lecture: 623 Zn Lectures
Cousins 2007
Article: Weaver 2007
Article: Outten 2001


Oct 25/27: Newer Trace Elements (Mo, I, Mn, F, Ni) (Sunde)
Background: B, Mn, Mo, and Other Trace Elements, Stipanuk Chap. 40,41
Lecture: 623 Mo and Mn Lectures, Stipanuk Chap. 37
Lecture: 623 I, F, and Ni Lectures, Stipanuk Chap. 38
Molybdenum Cofactor (MoCo) Biosynthesis
Article: Vanderpas 1993
Article: Hausinger 2003
Article: Schwarz 2004


Nov 1/3: Likely and Potential Essential Elements (B, V, Si, Sn, Cr, As, W, Co, Cd, Li, Pb) (Sunde)
Lecture: 623 Likely Essential Mineral Lectures
Article: Eckhert 1998
Article: Busenlehner 2003
Article: Iwai 2006


Take-Home Final distributed Nov 3: due Friday, November 12
Exam: Take-Home Exam and accompanying article