IGPNS Faculty Mentors
Dale A. Schoeller, Ph.D.
1415 Linden Dr
Madison, WI 53706
2005 Atwater Award, United States Department of Agriculture- Agricultural Research Service.
Biochemical & Molecular Nutrition
Principal Research Interest:
Energy metabolism and human obesity, body composition, and stable isotope techniques for macronutrient metabolism.
Our research is focused on human obesity. We are investigating multiple aspects of the energy balance equation including body composition changes, interventions to change total energy expenditure using doubly labeled water, interventions that create small perturbations in energy and fat balance using a room calorimeter, dietary intake of sugar and several other foods using novel stable isotope methods, and the accuracy and precision of novel monitors for measurement of physical activity and dietary intake.
Our previous work has demonstrated that human obesity is not the simple result of low energy expenditure, but rather a complex interaction that results in a failure of the body to compensate for short periods of positive energy balance which accumulate over years and result in excessive weight gain. As a result of these findings, we have initiated a study of how moderate exercise may help enhance the acute hormonal response of the hunger and satiety system leading to better dietary compensation following brief periods of overeating.
We have also begun to key on dietary intake, particularly with respect to the influence of high intakes of caloric sweeteners. In the US, caloric sweeteners are largely sugar and high fructose corn syrup. These two simple carbohydrates have an unusually high 13C natural abundance and we initiated several studies that use isotope ratio mass spectrometry to measure isotopic differences at the natural abundance level for the purpose of assessing dietary intake of caloric sweeteners and other foods.
Finally, we joined forces with a group of collaborating investigators here at the University of Wisconsin who are concentrating research efforts on the prevention of pediatric obesity and diabetes. Efforts include community and school based interventions, dietary interventions, built environment assessments, as well as more basic studies. It is our hope that our combined efforts will help reverse the pediatric obesity trends in Wisconsin.
Schoeller DA. The energy balance equation: looking back and looking forward are two very different views. Nutrition Rev. 2009; 67(5):249-54.
Cooper JA, Watras AC, Adams AK, Schoeller DA. Effects of dietary fatty acid composition on 24-hour energy expenditure and chronic disease risk factors in men. Am J Clin Nutr. 2009; 89:1350-6.
Dugas LR, Ebersole K, Schoeller D, Yanovski JA, Barquera, Rivera J, Durazo-Arzivu R, Luke A. Very low levels of physical activity among pre-adolescent Mexican-American girls. Int J Ped Obesity. 2008; 3:123-6.
Heymsfield SB, Harp JB, Reitman ML, Beetsch JW, Schoeller DA, Erondu N, Pietrobelli A. Why do obese patients not lose more weight when treated with low-calorie diets? A mechanistic perspective. Am J Clin Nutr. 2007;85:346-54.
Hansen KC, Zhang Z, Gomez T, Adams AK, Schoeller DA.R. Exercise increases the proportion of fat utilization during short-term consumption of a high-fat diet. Am J Clin Nutr. 2007; 85:109-16.
Blanc S, Schoeller DA, Bauer D, Danielson ME, Tylavsky F, Simonsick EM, Harris TB, Kritchevsky SB, Everhart JE. Energy requirements in the eighth decade of life. Am J Clin Nutr. 2004; 79:303-10. [Abstract]
Subar AF, Kipnis V, Troiano RP, Midthune D, Schoeller DA, Bingham S, Sharbaugh CO, Trabulsi J, Runswick S, Ballard-Barbash R, Sunshine J, Schatzkin A. Using intake biomarkers to evaluate the extent of dietary misreporting in a large sample of adults: the OPEN study. Am J Epidemiol. 2003;158:1-13. [Abstract]
Votruba, S.B., Blanc, S., Schoeller, D.A. Pattern and cost of weight gain in previously obese women. Am. J. Physiol. 282:E923-E930, 2002 [Abstract]