IGPNS Faculty Mentors

Tomas Prolla, Ph.D.

Tomas Prolla, Ph.D.5264 Biotech Center
Madison WI 53706

Emphasis Group:
Biochemical & Molecular Nutrition

Principal Research Interest:
My laboratory is currently focused on understanding the molecular basis of the aging process and common age-related human diseases through the use of large-scale gene expression analysis. We have recently characterized thegene expression profile of thousands of genes during the aging process of skeletal muscle and brain using "DNA-chips." We are currently extending these studies to multiple tissues of mice, humans and rhesus monkeys. We complement these studies with the generation of transgenic and "knock-out" mice that overexpress or are deficient in specific genes, and analyze the influence of these interventions on the aging process. Other studies include the effects of DNA repair pathways in cancer, and the role of micronutrients such as selenium in cancer prevention.

Representative Publications:

Edwards MG, Anderson RM, Yuan M, Kendziorski CM, Weindruch R, Prolla TA. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program. BMC Genomics. 2007 Mar 23;8:80.

Kujoth GC, Bradshaw PC, Haroon S, Prolla TA. The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet. 2007 Feb 23;3(2):e24.

Weindruch R, Kayo T, Lee CK, Prolla TA. Effects of caloric restriction on gene expression. Nestle Nutr Workshop Ser Clin Perform Programme. 2002;6:17-28

Someya S, Yamasoba T, Weindruch R, Prolla TA, Tanokura M. Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis. Neurobiol Aging. 2007 Oct;28(10):1613-22.

Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005 Jul 15;309(5733):481-4.