Pamela J. Kling, M.D.
6C Neonatology
202 S. Park Street
Madison, WI 53715
608-262-6561 or 608-267-5867
pkling@wisc.edu
Emphasis Group:
Human Nutrition
Principal Research Interest
Erythropoiesis, Iron Metabolism and Roles of Erythropoietin in Early Development
Research Summary:
We are studying the interactions between iron and erythropoiesis
(red blood cell production) in early development. Erythropoietin,
the primary hormone regulating erythropoiesis, has recently been shown
to play diverse biologic roles apart from its ability to stimulate
red blood cell production. We are examining this role of erythropoietin
in early development, including its effects on gastrointestinal devleopment.
We are examining the role of iron in the both erythropoietic and nonerythropoietic
functions of erythropoietin in early development. We are utilizing
newborn rats for these organ studies and have developed a model of
iron deficiency in newborn rats. We are studying clinical measures
(biomarkers) of iron status, with the goal that iron deficiency in
later infancy can be predicted by iron measurements at the time of
birth.
Representative Publications
Kling PJ, Taing KM, Dvorak B, Woodward SS, Grille JG, Philipps AF. Insulin-like
growth factor-I stimulates erythropoiesis when administered enterally.
Growth Factors 2006:24;218-223.
Lesser KB, Schoel SB, Kling PJ. Elevated zinc protoporphyrin/heme ratios in umbilical
cord blood after diabetic pregnancy. J Perinatol 2006:26;671-676.
Kleven KJ, Blohowiak SB, Kling PJ. Zinc protoporphyrin/heme
ratios in large for gestation newborns. Neonatology 2007:92:91-95.
Kling PJ, Willeitner A, Dvorak B, Blohowiak SE. Milk-borne
erythropoietin and iron stimulate erythropoiesis in suckling rats. J
Pediatr Gastroent Nutr 2008:46;202-207.
Baumann-Blackmore NL, Goetz E, Blohowiak SE, Zaka O, Kling
PJ. Cord blood zinc protoporphyrin/heme ratio in minority neonates at-risk
for iron deficiency. J Pediatr 2008:153;133-136.
Blohowiak SE, Chen ME, Repyak KS, Baumann-Blackmore NL, Carlton
DP, Georgieff MK, Crenshaw TD, Kling PJ. Reticulocyte enrichment of zinc
protoporphyrin/heme discriminates impaired iron supply during early development,
Pediatr Res 2008:64;63-67.
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