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Pamela J. KlingPamela J. Kling, M.D.

6C Neonatology
202 S. Park Street
Madison, WI 53715
608-262-6561 or 608-267-5867
pkling@wisc.edu

Emphasis Group:
Human Nutrition

Principal Research Interest
Erythropoiesis, Iron Metabolism and Roles of Erythropoietin in Early Development

Research Summary:
We are studying the interactions between iron and erythropoiesis (red blood cell production) in early development. Erythropoietin, the primary hormone regulating erythropoiesis, has recently been shown to play diverse biologic roles apart from its ability to stimulate red blood cell production. We are examining this role of erythropoietin in early development, including its effects on gastrointestinal devleopment. We are examining the role of iron in the both erythropoietic and nonerythropoietic functions of erythropoietin in early development. We are utilizing newborn rats for these organ studies and have developed a model of iron deficiency in newborn rats. We are studying clinical measures (biomarkers) of iron status, with the goal that iron deficiency in later infancy can be predicted by iron measurements at the time of birth.

Representative Publications

Kling PJ, Taing KM, Dvorak B, Woodward SS, Grille JG, Philipps AF. Insulin-like growth factor-I stimulates erythropoiesis when administered enterally. Growth Factors 2006:24;218-223.

Lesser KB, Schoel SB, Kling PJ. Elevated zinc protoporphyrin/heme ratios in umbilical cord blood after diabetic pregnancy. J Perinatol 2006:26;671-676.

Kleven KJ, Blohowiak SB, Kling PJ. Zinc protoporphyrin/heme ratios in large for gestation newborns. Neonatology 2007:92:91-95.

Kling PJ, Willeitner A, Dvorak B, Blohowiak SE. Milk-borne erythropoietin and iron stimulate erythropoiesis in suckling rats. J Pediatr Gastroent Nutr 2008:46;202-207.

Baumann-Blackmore NL, Goetz E, Blohowiak SE, Zaka O, Kling PJ. Cord blood zinc protoporphyrin/heme ratio in minority neonates at-risk for iron deficiency. J Pediatr 2008:153;133-136.

Blohowiak SE, Chen ME, Repyak KS, Baumann-Blackmore NL, Carlton DP, Georgieff MK, Crenshaw TD, Kling PJ. Reticulocyte enrichment of zinc protoporphyrin/heme discriminates impaired iron supply during early development, Pediatr Res 2008:64;63-67.